IHT Rendezvous: IHT Quick Read: Dec. 24

NEWS An Islamist-backed constitution was approved by voters in Egypt, propelling deeply split political factions into a new phase in the battle over the country’s future. David Kirkpatrick and Mayy El Sheikh report from Cairo.

Angry protests escalated into violence in India’s capital Sunday, after thousands of people gathered to demand justice for the victim of a recent gang rape in New Delhi. Heather Timmons and Gardiner Harris report.

The latest chapter in the Greek fiscal drama is a new reminder of how private investors have managed to outmaneuver Europe’s officials at various stages of the debt crisis. And, some experts caution, each time it happens, future debt workouts in the euro zone will become even more costly. Landon Thomas Jr. reports from London.

Alongside Christmas markets peddling sweets, candles, holiday decorations and crafts another kind of market has sprung up in response to Spain’s hard times: “mercadillos,” or little markets, where the entrepreneurial-minded have found a niche by gathering and selling the unsold stock of retailers whose sales have plummeted, or unwanted clothing and other items from people in need of cash. Raphael Minder reports from Madrid.

Owners of dozens of buildings across Hong Kong drape the exteriors with enormous displays for Christmas, New Year and the Lunar New Year — an expense that appears to be downturn-proof. Bettina Wassener reports.

EDUCATION Elite Western boarding schools, including Marlborough College, the Harrow School and Branksome Hall, are establishing campuses in Asia. The schools are tapping into the demands of Asian parents who want their children to get a high-quality foreign-style education while staying close to home. There is also the desire to escape local school systems, which focus more on exams and rote learning. Kristiano Ang and Yenni Kwok report.

Malaysia is trying to upgrade a hodgepodge of gritty industrial towns and rural villages with Iskandar Malaysia, a planned eco-city and trading zone with districts for tourism, health care and education. EduCity, a 240-hectare, or 600-acre, plot of land is being developed in Nusajaya, with the hope that the city’s lush green fields, neatly paved roads and two theme parks will eventually become a second home to more than 16,000 students. Kristiano Ang reports from Nusajaya, Malaysia.

ARTS The austerity measures that have hurt the arts across Europe have been particularly unsettling in France, where cultural spending had been sacrosanct. Now the directors of grand cultural institutions here are resorting to public appeals to pay for the things they want, cobbling together the money not by courting millionaires but just the average Jules. Doreen Carvajal reports from Paris.

Many of the year’s design coups belonged to small entrepreneurs. Alice Rawsthorn writes from London.

SPORTS The Indian batting legend Sachin Tendulkar announced that he is retiring from one-day cricket events, implying that he intends to continue in five-day tests, taking a career that began when he was 16 up to and beyond his 40th birthday next March. Huw Richards reports.

With the goalkeeper and club captain Iker Casillas sitting on the bench for the first time since May 2002, Real Madrid suffered its first loss to Málaga since 1983. Rob Hughes on soccer.

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RIM shares fall at the open after earnings

TORONTO (Reuters) – Research In Motion Ltd fell in early trading on Friday following the BlackBerry maker’s Thursday earnings announcement, when the company outlined plans to change the way it charges for services.

RIM, pushing to revive its fortunes with the launch of its new BlackBerry 10 devices next month, surprised investors when it said it plans to alter its service revenue model, a move that could put the high-margin business under pressure.

Shares fell 16.0 percent to $ 11.86 in early trading on the Nasdaq. Toronto-listed shares fell 15.8 percent to C$ 11.74.

(Reporting by Allison Martell; Editing by Gerald E. McCormick)

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Seahawks roll past 49ers in noisy Seattle 42-13

SEATTLE (AP) — Red Bryant remembers the early years of his career, when the Seattle Seahawks struggled to win only four and five games in his first two seasons.

Getting a 10th win on Sunday night and a trip to the postseason was special to the Seahawks' big defensive end.

"Who has been playing better than us the last few weeks?" Bryant questioned. "This is the National Football League and you don't get any gimmies. We work hard to win. ... It's hard to win in this league."

Russell Wilson threw a career-high four touchdown passes to move into second place for most TD passes by a rookie, Marshawn Lynch scored two first-quarter TDs, and the Seahawks routed the San Francisco 49ers 42-13.

Richard Sherman returned Bryant's blocked field goal 90 yards for another touchdown as the Seahawks (10-5) jumped to a 21-0 lead. That only added to an already hyped crowd on a typically cold and rainy December night, with noise echoing off the walls and overhanging roof of CenturyLink Field that might have been heard all the way across Puget Sound.

No one appeared to care about the weather, not with the performance they were seeing on the field. And not with a ticket to the postseason guaranteed thanks to Seattle's first 10-win season since 2007.

"We knew we were capable of doing this. We had no doubt. Even in Week 1, we knew that we had the talent to do what we're doing now," said wide receiver Doug Baldwin, who had two touchdown receptions. "It took time because we're a young team. We had to mature. We had to grow together, build that chemistry, build that trust out there on the field. That's the most important thing."

Seattle surged into the playoffs on the strength of its sixth win in seven games, putting up dizzying offensive numbers that no one thought would continue against the top scoring defense in the NFL but did.

Seattle has outscored its last three opponents 150-30. The 42 points were the most allowed since Jim Harbaugh took over the 49ers, and the most San Francisco yielded since giving up 45 to Atlanta in 2009. It was the perfect way for Seattle coach Pete Carroll to snap a three-game losing streak against his rival.

"We just try to play really good football and see what happens at the end," Carroll said. "We have been scoring and doing a nice job of it and it would be great If we can keep it rolling."

Seattle will likely be the No. 5 seed in the NFC. There remains a slight chance of winning the NFC West, if the Seahawks beat St. Louis in the season finale and Arizona can upset the 49ers in San Francisco.

The Seahawks, 7-0 at home, delayed San Francisco (10-4-1) from celebrating a division title. They turned Harbaugh's 49th birthday into a miserable evening.

"If you had told me this would be the outcome I wouldn't have believed it," Sherman said. "I would say you're making this up."

Wilson hit Lynch on a 9-yard TD in the first quarter, Anthony McCoy for a 6-yarder late in the first half, and Doug Baldwin on 4 and 6 yard TDs in the second half.

Wilson has 25 TD passes, one behind Peyton Manning's NFL rookie record of 26. He finished 15 of 21 for 171 yards. His only incompletion in the first half was a deflected pass that Patrick Willis intercepted.

Wilson's counterpart, San Francisco's Colin Kaepernick, had already proven himself capable of winning on the road with victories in New Orleans and last week in New England. But Seattle is a different beast, widely regarded by players as the loudest venue in the NFL. His inexperience playing in such an environment showed. He was flustered and disorganized at the line of scrimmage, letting the noise from Seattle's fans affect him.

Kaepernick's forgettable night was capped when Sherman stepped in front of his pass intended for Randy Moss at the back of the end zone on the first play of the fourth quarter for his seventh interception of the season.

Kaepernick was 19 of 36 for 244 yards with an 18-yard TD pass to Delanie Walker with 1:40 left. Frank Gore had just 28 yards on six carries after rushing for a season-high 131 when the teams met in Week 7.

"Every time you are on the field you are learning something," Kaepernick said. "We just have to take what we can from this game and move on to next week."

San Francisco played without defensive tackle Justin Smith due to an elbow injury that ended a streak of 185 starts. The 49ers lost tight end Vernon Davis in the first quarter with a concussion sustained when he was knocked off his feet on a huge hit along the sideline from Seattle safety Kam Chancellor that looked legal but drew a penalty for hitting a defenseless receiver.

San Francisco wide receiver Mario Manningham went down with a left leg injury early in the third quarter when he was tackled low by Leroy Hill and fumbled.

The loss of Smith affected the entire defense. Aldon Smith was left stuck on 19 1-2 sacks after being locked up by Seattle offensive tackle Russell Okung.

"We can't make excuses," 49ers' safety Donte Whitner said. "We understand: We lost the football game; we lost an ugly football game."

NOTES: Lynch finished with 111 yards on 26 carries, his third straight game over 100 yards vs. the 49ers. ... Seattle was 11 of 13 on third-down conversions, a season-high. ... The 49ers were held to 82 yards rushing, just the third time this season he was held under 100 yards.

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N.Y.U. and Others Offer Shorter Courses Through Medical School

Training to become a doctor takes so long that just the time invested has become, to many, emblematic of the gravity and prestige of the profession.

But now one of the nation’s premier medical schools, New York University, and a few others around the United States are challenging that equation by offering a small percentage of students the chance to finish early, in three years instead of the traditional four.

Administrators at N.Y.U. say they can make the change without compromising quality, by eliminating redundancies in their science curriculum, getting students into clinical training more quickly and adding some extra class time in the summer.

Not only, they say, will those doctors be able to hang out their shingles to practice earlier, but they will save a quarter of the cost of medical school — $49,560 a year in tuition and fees at N.Y.U., and even more when room, board, books, supplies and other expenses are added in.

“We’re confident that our three-year students are going to get the same depth and core knowledge, that we’re not going to turn it into a trade school,” said Dr. Steven Abramson, vice dean for education, faculty and academic affairs at N.Y.U. School of Medicine.

At this point, the effort involves a small number of students at three medical schools: about 16 incoming students at N.Y.U., or about 10 percent of next year’s entering class; 9 at Texas Tech Health Science Center School of Medicine; and even fewer, for now, at Mercer University School of Medicine’s campus in Savannah, Ga. A similar trial at Louisiana State University has been delayed because of budget constraints.

But Dr. Steven Berk, the dean at Texas Tech, said that 10 or 15 other schools across the country had expressed interest in what his university was doing, and the deans of all three schools say that if the approach works, they will extend the option to larger numbers of students.

“You’re going to see this kind of three-year pathway become very prominent across the country,” Dr. Abramson predicted.

The deans say that getting students out the door more quickly will accomplish several goals. By speeding up production of physicians, they say, it could eventually dampen a looming doctor shortage, although the number of doctors would not increase unless the schools enrolled more students in the future.

The three-year program would also curtail student debt, which now averages $150,000 by graduation, and by doing so, persuade more students to go into shortage areas like pediatrics and internal medicine, rather than more lucrative specialties like dermatology.

The idea was supported by Dr. Ezekiel J. Emanuel, a former health adviser to President Obama, and a colleague, Victor R. Fuchs. In an editorial in the Journal of the American Medical Association in March, they said there was “substantial waste” in the nation’s medical education. “Years of training have been added without evidence that they enhance clinical skills or the quality of care,” they wrote. They suggested that the 14 years of college, medical school, residency and fellowship that it now takes to train a subspecialty physician could be reduced by 30 percent, to 10 years.

That opinion, however, is not universally held. Other experts say that a three-year medical program would deprive students of the time they need to delve deeply into their subjects, to consolidate their learning and to reach the level of maturity they need to begin practicing, while adding even more pressure to a stressful academic environment.

“The downside is that you are really tired,” said Dr. Dan Hunt, co-secretary of the Liaison Committee on Medical Education, the accrediting agency for medical schools in the United States and Canada. But because accreditation standards do not dictate the fine points of curriculum, the committee has approved N.Y.U.’s proposal, which exceeds by five weeks its requirement that schools provide at least 130 weeks of medical education.

The medical school is going ahead with its three-year program despite the damage from Hurricane Sandy, which forced NYU Langone Medical Center to evacuate more than 300 patients at the height of the storm and temporarily shut down three of its four main teaching hospitals.

Dr. Abramson of N.Y.U. said that postgraduate training, which typically includes three years in a hospital residency, and often fellowships after that, made it unnecessary to try to cram everything into the medical school years. Students in the three-year program will have to take eight weeks of class before entering medical school, and stay in the top half of their class academically. Those who do not meet the standards will revert to the four-year program.

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At Western Wall, a Divide Over Prayer Deepens

Rina Castelnuovo for The New York Times

Members of Women of the Wall prayed this month while wearing tallits, fringed prayer shawls, and tefillin, leather prayer boxes, both of which Jewish men are told to wear.

JERUSALEM — The face-off at the security gate outside the Western Wall one Friday this month was familiar: for more than two decades, women have been making a monthly pilgrimage to pray at one of Judaism’s holiest sites in a manner traditionally preserved for men, and the police have stopped them in the name of maintaining public order.

Rina Castelnuovo for The New York Times

Bonna Devora Haberman, 52, of Women of the Wall, was confronted by the police this month after trying to bring in her prayer shawl.

But after a flurry of arrests this fall that set off an international outcry, the women arrived for December’s service to find a new protocol ordered by the ultra-Orthodox rabbi who controls the site. To prevent the women from defying a Supreme Court ruling that bars them from wearing ritual garments at the wall, they were blocked by police officers from bringing them in.

“How can you say this to me?” demanded a tearful Bonna Devora Haberman, 52, a Canadian immigrant who helped found the group Women of the Wall in 1988. “I’m a Jew. This is my state.”

The officer was unmoved. “At the Western Wall, you can’t pray with a tallit,” he said, referring to the fringed prayer shawl in Ms. Haberman’s backpack. “You can’t go in with it.”

After years of legislative and legal fights, the movement for equal access for people to pray as they wish at the site has become a rallying cause for liberal Jews in the United States and around the world, though it has long struggled to gain traction here in Israel, where the ultra-Orthodox retain great sway over public life.

This has deepened a divide between the Jewish state and the Jewish diaspora, in which some leaders have become increasingly vocal in criticizing Israel’s policies on settlements in the Palestinian territories; laws and proposals that are seen as antidemocratic or discriminatory against Arab citizens; the treatment of women; and the ultra-Orthodox control over conversion and marriage.

“When my kids start expressing frustration with Israel as a society because what they hear and see from a distance is not welcoming to them in their religious practice — that’s not good for the Jewish people, let alone for the state of Israel,” said Rabbi Steven C. Wernick, the director of the United Synagogue of Conservative Judaism.

Rabbi Levi Weiman-Kelman, an American immigrant who runs Kol Haneshama, a leading Reform synagogue here, said Women of the Wall “is an issue that really brings out the gap between Israeli Jews and American Jews.”

While more than 60 percent of Jews in the United States identify with the Reform or Conservative movements, where women and men have equal standing in prayer and many feminists have adopted ritual garments, in Israel it is one in 10. Instead, about half call themselves secular, and experts say that most of those consider Orthodoxy as the true Judaism, feel alienated from holy sites like the Western Wall, and view a woman in a prayer shawl as an alien import from abroad.

(Jewish law requires only men to pray daily, though many women have taken on the obligation voluntarily. It also says women should not dress like men.)

“Secular Israelis do not see this as their problem; to them it’s a bunch of crazy American ladies,” said Shari Eshet, who represents the New York-based National Council of Jewish Women here. “It’s embarrassing for Israel, it’s embarrassing for Jews, and the American Jewish community is beginning to understand that it’s a slippery slope here.”

The increased agitation around the wall is part of a broader clash over Judaism and gender that has roiled Israel in recent months. Women have won lawsuits against segregation on buses and sidewalks imposed in religious neighborhoods. But a bus line recently stopped accepting advertisements with images of people after religious vandals routinely blacked out women’s faces in the name of modesty.

In January, speakers at a conference on health and Jewish law canceled their appearances because women were barred from the podium — a demand of the most Orthodox — while the chief rabbi of the air force quit after religious soldiers were not excused from events where women sang.

These controversies concern the imposition of Orthodox doctrine in secular spheres. More complicated are questions of how Judaism itself should be practiced. This spring, the Supreme Court ruled that the government must pay the salary of a Reform rabbi along with hundreds of Orthodox ones. A small group of Jerusalem restaurants has been seeking an alternative kosher certification system to the one run by the government’s rabbinical council.

“The next chapter of what it means to be a Jewish state is being defined right now,” said Elana Sztokman, the director of the Jewish Orthodox Feminist Alliance, who is writing a book that includes a chapter about Women of the Wall. “We have to figure out what does Israel want, what role do we really want religion to have in this state? And it’s happening on the backs of women.”

Irit Pazner Garshowitz and Myra Noveck contributed reporting.

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Facebook’s SnapChat-Style Sexting App Is Called Poke (Seriously)

Oh, well would you look at Facebook, trying to make a Christmas funny with its SnapChat copycat app. It’s called Poke! Get it? Because SnapChat is what the kids are all using for their sexting these days, apparently, and Poke — you know, that once kinda flirty Facebook future that’s now pretty much useless — can kind of do the same thing, and it kind of sounds like some bad sexual pun, too! Funny, Facebook, very funny, and way to admit the dirty little truth behind “poking” that we knew all along.

RELATED: Facebook to Launch Its Own SnapChat as Social-Network Clone Wars Live on

Oh, wait. They’re serious? Oh, yeah: Friday afternoon Facebook released Poke, its rumored iPhone app for the incredible vanishing half-message “that makes it fun and easy to say hello to friends wherever you are.” But don’t get too heavy on the old-school “Poke” comparisons, because the new app can actually send regular messages, photos, or videos, too — but only for short periods of time, because that is apparently what the kids like doing these days, if SnapChat’s huge success is any indication. There’s more of a time-bomb component to Poke, though: users can choose how long someone sees a poke before it ceases to exist forever — so you could sext poke all day long, because that, too, is apparently what the kids like doing these days, if SnapChat’s huge, smashing, sexy success is any indication.

RELATED: The Life and Philosophy of Mark Zuckerberg

Why would anyone use Poke over SnapChat? Well, the Facebook app itself has a much smoother interface than SnapChat, and you can report people behaving badly, and everyone’s already on Facebook, right? Maybe this is the breaking point Justin Bieber could never hit, when something sexy goes from the tween set to actual human beings. We’ll let you know when Poke shows up in our iPhone’s App Store; for now we’re not entirely sure if this is just some bad joke. (Although it is in the iTunes Store, so… we’ll see?)

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Falcons top Lions 31-18 for home-field advantage

DETROIT (AP) — Matt Ryan got what he wanted.

Calvin Johnson was forced to settle for what he could get.

Ryan matched a career high with four touchdown passes, two to Roddy White, to help the Atlanta Falcons beat the Detroit Lions 31-18 Saturday night and earn home-field advantage throughout the NFC playoffs.

"It's great," Ryan said. "Our confidence is high and our experience — good and bad — has helped us. The key is to keep the focus where it's been."

In yet another loss, Johnson had a record-breaking night.

Johnson broke Jerry Rice's NFL single-season yards receiving mark of 1,848. After making the record-breaking catch in the fourth quarter, Johnson jogged over to the sideline and handed the football to his father.

"That was a very special moment," he said.

Johnson also became the only player with 100 yards receiving in eight straight games and the first with 10 receptions in four games in a row in league history. He had 11 receptions for 225 yards, giving him 1,892 this season.

"I've been an NFL fan my whole life, dating back to watching Johnny Unitas and Raymond Berry as a kid, and I've coached in this league for 19 years," Detroit coach Jim Schwartz said. "I've seen a lot of Hall of Famers, but I've never seen a better player than Calvin Johnson.

"He just broke a record set by Jerry Rice, who is arguably the best player in this history of this league."

The Falcons (13-2) pulled away with Ryan's fourth TD pass to wide-open tight end Michael Palmer in the fourth quarter and Matt Bryant's 20-yard field goal with 3:05 left that gave them a 15-point lead.

Ryan was 25 of 32 for 279 yards without a turnover.

The Falcons hope playing at home, potentially throughout the conference playoffs, helps them more than it did after the 2010 and 1980 seasons. The Falcons failed to win a game in either postseason, getting routed by Green Bay two years ago and blowing a double-digit, fourth-quarter lead to Dallas three decades ago.

Atlanta advanced to its only Super Bowl with a win at Minnesota after winning a franchise-record 14 games during the 1998 season.

The Falcons won't have much incentive to match that mark next week at home against Tampa Bay, when they'll have nothing to gain and something to lose if a key player or more gets hurt.

Detroit (4-11) has been relegated to playing for pride this month and that hasn't been going very well.

The Lions, whose seven-game losing streak is the longest skid in the league, haven't struggled this much since the laughingstock of a franchise became the league's first to go 0-16 in 2008.

The Falcons led 21-3 at halftime before letting the Lions pull within five points early in the fourth quarter.

Ryan dashed Detroit's comeback hopes.

Facing intense pressure, he converted a third down in Atlanta territory with a pass to White, picked on rookie cornerback Jonte Green by throwing to Jones to pick up more first downs and found Tony Gonzalez open to convert another third down to set up his fourth TD pass.

"We didn't play well in the third quarter," Atlanta coach Mike Smith said. "Matt made some big throws on that drive."

Stafford was clearly trying to get the ball to Johnson on the next drive and cornerback Asante Samuel figured that out, stepping in front of the receiver for an interception to set up Bryant's field goal.

Atlanta running back Michael Turner was tackled in the end zone, after Detroit turned the ball over on downs, to give the Lions two meaningless points.

Ryan went deep to White for the first score, connecting with him on a 44-yard TD strike with 5:50 left in the first quarter. Ryan threw a short pass to him early in the second quarter and the standout receiver did the rest on a 39-yard sprint down the sideline.

Ryan put his third TD pass where only Julio Jones could catch it a corner of the end zone, and he did on a 16-yard reception that put Atlanta up 21-3.

Detroit didn't give up, a game after being accused of doing just that in a 38-10 loss at Arizona.

Jason Hanson kicked a second field goal late in the first half to make it 21-6.

After Atlanta opened the second half with a three-and-out drive, Mikel Leshoure scored on a 1-yard run midway through the third quarter to pull the Lions with eight points.

Hanson's third field goal made it 21-16.

Stafford finished 37 of 56 for 443 yards with an interception and the Lions say he set an NFL record for the most yards passing in a game without throwing a TD pass.

Detroit dug a big hole because the Falcons scored two TDs off turnovers in the first half.

Defensive end Kroy Biermann forced running Leshoure to fumble, giving the Falcons the ball at their 31 and they took advantage. Ryan's perfectly lofted pass to White's fingertips converted a third-and-1 in a big way, putting the Falcons ahead.

The Lions responded with another drive into Atlanta territory, but stalled and had to settle for Hanson's 34-yard field goal in the final minute of the opening quarter to pull within four points.

Atlanta earned a double-digit lead on the ensuing drive.

Ryan threw a screen pass to his left to White, who got a great block from tight end Gonzalez, and the receiver raced untouched for a score that put the Falcons ahead 14-3.

White finished with eight receptions for 153 yards and two TDs. Jones had seven receptions for 71 yards and a score.

Ryan completed his first 12 attempts and, after his first incomplete pass, he converted a third-and-10 with an 11-yard toss to Jacquizz Rodgers. Two plays later, Ryan matched a season high with a third TD pass on the connection with Jones. Prior to the game, Ryan hadn't started a game with more than 10 consecutive completions, according to STATS LLC. He started 10 for 10 last month against Tampa Bay.

Johnson had three receptions for 70 yards in the first quarter, breaking Herman Moore's single-season franchise record for yards receiving.

By halftime, Johnson had 117 yards receiving. He had 100 yards receiving for an eighth straight game, breaking a record set by Charley Hennigan in 1961 and matched by Michael Irvin in 1995. It was Johnson's 11th game with 100 yards receiving this season, tying Irvin's NFL mark.

"Calvin is one of the best players in the game and I think everybody is a big fan of his," Ryan said. "He's one of the most genuinely nice people you could meet."

Stafford connected with Johnson on a short crossing route and the receiver did the rest, outrunning Falcons on a 49-yard gain. Fittingly, the Lions turned the ball over on the next snap in the latest lowlight in a season full of them.

The Lions, Falcons and fans at Ford Field in Detroit honored the victims of the shootings at Sandy Hook Elementary School before the game. Players had memorial decals on their helmets that read "S.H.E.S." in white on a black background, and Detroit's coaches wore pins with a similar design. There was also a moment of silence before the national anthem while the names and ages of each victim were shown on the videoboards. Twenty children and six adults were killed in the Dec. 14 shooting in Newtown, Conn. Adam Lanza killed his mother, shot students and staff, then killed himself.

NOTES: Stafford, in his fourth season, has 1,090 career completions to surpass Bobby Layne's franchise record of 1,074. Stafford is seven attempts away from surpassing the NFL's single-season mark of 691 set by Drew Bledsoe with New England in 1994. ... Backup Falcons CB Christopher Owens had a hamstring injury.

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Genetic Gamble : Drugs Aim to Make Several Types of Cancer Self-Destruct

C.J. Gunther for The New York Times

Dr. Donald Bergstrom is a cancer specialist at Sanofi, one of three companies working on a drug to restore a tendency of damaged cells to self-destruct.

For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated — breast, prostate, liver, lung. The drugs go after an aberration involving a cancer gene fundamental to tumor growth. Many scientists see this as the beginning of a new genetic age in cancer research.

Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have many different kinds of cancer, researchers and federal regulators say. “This is a taste of the future in cancer drug development,” said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. “I expect the organ from which the cancer came from will be less important in the future and the molecular target more important,” he added.

And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fund-raising for particular cancers to pushing for research aimed at many kinds of cancer at once, Dr. Brawley said. John Walter, the chief executive officer of the Leukemia and Lymphoma Society, concurred, saying that by pooling forces “our strength can be leveraged.”

At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work. Seven years ago, he went into the hospital for hernia surgery, only to learn he had liposarcoma, a rare cancer of fat cells. A large tumor was wrapped around a cord that connects the testicle to the abdomen. “I was shocked,” he said in an interview this summer.

Companies have long ignored liposarcoma, seeing no market for drugs to treat a cancer that strikes so few. But it is ideal for testing Sanofi’s drug because the tumors nearly always have the exact genetic problem the drug was meant to attack — a fusion of two large proteins. If the drug works, it should bring these raging cancers to a halt. Then Sanofi would test the drug on a broad range of cancers with a similar genetic alteration. But if the drug fails against liposarcoma, Sanofi will reluctantly admit defeat.

“For us, this is a go/no-go situation,” said Laurent Debussche, a Sanofi scientist who leads the company’s research on the drug.

The genetic alteration the drug targets has tantalized researchers for decades. Normal healthy cells have a mechanism that tells them to die if their DNA is too badly damaged to repair. Cancer cells have grotesquely damaged DNA, so ordinarily they would self-destruct. A protein known as p53 that Dr. Gary Gilliland of Merck calls the cell’s angel of death normally sets things in motion. But cancer cells disable p53, either directly, with a mutation, or indirectly, by attaching the p53 protein to another cellular protein that blocks it. The dream of cancer researchers has long been to reanimate p53 in cancer cells so they will die on their own.

The p53 story began in earnest about 20 years ago. Excitement ran so high that, in 1993, Science magazine anointed it Molecule of the Year and put it on the cover. An editorial held out the possibility of “a cure of a terrible killer in the not too distant future.”

Companies began chasing a drug to restore p53 in cells where it was disabled by mutations. But while scientists know how to block genes, they have not figured out how to add or restore them. Researchers tried gene therapy, adding good copies of the p53 gene to cancer cells. That did not work.

Then, instead of going after mutated p53 genes, they went after half of cancers that used the alternative route to disable p53, blocking it by attaching it to a protein known as MDM2. When the two proteins stick together, the p53 protein no longer functions. Maybe, researchers thought, they could find a molecule to wedge itself between the two proteins and pry them apart.

The problem was that both proteins are huge and cling tightly to each other. Drug molecules are typically tiny. How could they find one that could separate these two bruisers, like a referee at a boxing match?

In 1996, researchers at Roche noticed a small pocket between the behemoths where a tiny molecule might slip in and pry them apart. It took six years, but Roche found such a molecule and named it Nutlin because the lab was in Nutley, N.J.

But Nutlins did not work as drugs because they were not absorbed into the body.

Roche, Merck and Sanofi persevered, testing thousands of molecules.

At Sanofi, the stubborn scientist leading the way, Dr. Debussche, maintained an obsession with p53 for two decades. Finally, in 2009, his team, together with Shaomeng Wang at the University of Michigan and a biotech company, Ascenta Therapeutics, found a promising compound.

The company tested the drug by pumping it each day into the stomachs of mice with sarcoma.

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Midge Turk Richardson, Ex-Nun Who Edited Seventeen Magazine, Dies at 82

Midge Turk Richardson, who spent 18 years as a nun before spending 18 years as the editor of Seventeen magazine, a redoubt of worldly concerns like clothes, makeup and dating, died last weekend at her home in Manhattan. She was 82.

Mrs. Richardson, whose body was found by family members on Monday, apparently died in her sleep sometime during the weekend, her stepson Kevin Richardson said.

A former Roman Catholic nun, Mrs. Richardson left her order in 1966, a journey she recounted in a memoir, “The Buried Life,” published in 1971. In secular life, she became a member of New York’s social set, and was married for three decades to Ham Richardson, a tennis star who later ran his own investment concern, with homes on Park Avenue and in Bridgehampton, on Long Island.

At Seventeen, which she edited from 1975 until her retirement in 1993, Mrs. Richardson was known for introducing frank discussions of delicate subjects — including sex, anorexia and suicide — from which the magazine, aimed at teenage girls and long considered a bastion of wholesomeness, had traditionally shied away.

Under Mrs. Richardson’s stewardship, certain aspects of the magazine remained comfortably familiar. “Secrets of Staying Thin,” promised one cover, from 1980; “Those Dreamy Summer Romances,” proclaimed another that year.

But other cover lines betrayed her resolve to address modern readers’ concerns: “Teen Suicide: The Danger Signals,” “What You Must Know About Herpes.”

In 1982, Mrs. Richardson instituted a regular column, “Sex and Your Body,” which explored subjects like gynecological health, sexual relations and birth control.

“We’ve been talking about it for years and trying to figure out how to go at it in a tasteful manner,” she told The Chicago Tribune in 1983. “We don’t want to be frightening to a young girl, or permissive. But the demands of the time finally brought us around to it.”

All this was a far cry from her life as Sister Agnes Marie, and from the quiet routine of her days in the convent, where she had lived from the ages of 18 to 36.

Agnes Theresa Turk, known as Midge because of her petite stature, was born in Los Angeles on March 26, 1930, the youngest daughter of a Roman Catholic family. As a girl, she worked as an extra in more than a hundred Hollywood films, sometimes appearing opposite Shirley Temple.

At 18, wanting a life of service, she forsook her lively home, her active social life and her boyfriend to enter the Sisters of the Immaculate Heart of Mary, a teaching order with a motherhouse in the Hollywood hills.

Sister Agnes Marie, as she was known in religion, earned bachelor’s and master’s degrees from Immaculate Heart College, run by her order. She embarked on a career as an educator, teaching English, French and drama in local parochial schools and later becoming the principal of a Catholic high school in a blighted, largely Latino section of Los Angeles.

She loved the life, but by the mid-1960s she had become depressed and exhausted — frustrated, she wrote, by what she saw as the failure of diocesan hierarchy to meet the needs of the impoverished community she served. She suffered two bouts of temporary blindness, brought on, her doctors told her, by strain.

In 1966, after much soul-searching, Sister Agnes Marie asked to be released from her vows. (In 1970, Anita Caspary, the mother superior of the Sisters of the Immaculate Heart, led an exodus of 300 nuns from the order in response to what they described as the failure of the diocese to lift outmoded restrictions on nuns’ lives.)

At 36, Agnes Turk found herself on her own for the first time. Carrying a single suitcase, she made for New York: it was one place, she reasoned, that offered career opportunities for women. She found a job as an assistant to a dean at New York University, sleeping on the floor of her tiny Greenwich Village apartment because she could not afford furniture.

She learned to navigate an alien social world. Once, preparing for a date, she washed her hair only to realize she did not own a hair dryer. She stuck her head pragmatically in the oven, emerging with singed hair.

After working as the college editor of Glamour magazine and at Scholastic Publications, she joined Seventeen as executive editor, becoming editor in chief in 1985.

Mrs. Richardson’s husband, whom she married in 1974, died in 2006. The No. 1-ranked tennis player in the United States in 1956 and 1958, he won 17 national titles and played on seven Davis Cup teams.

Besides her stepson Kevin, survivors include another stepson, Ken Richardson; a stepdaughter, Kit Sawers; two sisters, Gwendolyn Tighe and Marie Smith; and five step-grandchildren.

Mrs. Richardson was also the author of a children’s biography of a friend, the photographer Gordon Parks.

In an interview with The New York Times in 1970, she described the forces that led her first to take the veil and later to relinquish it:

“I entered the convent not so much because I believed in the church as that I believed in helping people,” she said. “I’d never had any great thing about dressing up in those clothes and jangling my rosary beads.”

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The Saturday Profile: In Cindy From Marzahn, an Offbeat Comedian of the People

WHEN a career counselor in the East German town of Luckenwalde asked Ilka Bessin what she wanted to be when she grew up, the teenager answered that she had always wanted to be a clown. “Cook” was also a creative job, the counselor suggested, and a lot more realistic.

It was still a few years before the fall of the Berlin Wall, and Ms. Bessin (pronounced bess-EEN) ended up an apprentice chef at a state-owned enterprise, preparing breakfast and lunch every day for more than 1,000 workers. She never could have guessed that two decades later she would be a comedy superstar in a reunified Germany, making millions of her compatriots laugh in clubs and theaters across the land, with television stations fighting over her appearances.

Audiences know Ms. Bessin, 41, as Cindy from Marzahn, her louder, ruder and more profane alter ego. With her curly peroxide wig and swathes of hot-pink eye shadow, Cindy hails from the notorious East Berlin neighborhood of Marzahn, synonymous with the enormous Communist high-rise housing estates.

An overweight 6-foot-2-inch Valkyrie of a woman in a pink velour sweatsuit, Cindy plays up the worst stereotypes of Germany’s contemporary version of the welfare queen. She wakes up at 2 o’clock in the afternoon and begins drinking. Her dream man, Enrico, stands 4-foot-10, weighs 375 pounds and works as a bouncer.

“No neck, no hair and no brain,” she says approvingly.

IN October, Ms. Bessin was named Germany’s female comedian of the year for the fourth time in a row. The daily newspaper Tagesspiegel recently called her “a phenomenon,” under the headline “Princess of the Plattenbau,” the prefabricated housing blocs built in the former East. She hosts her own television series and recently began appearing on “Wetten Dass,” the long-running variety show whose name translates loosely as “Wanna Bet?”

Yet when asked in a recent interview how it felt to be an established star, Ms. Bessin quickly replied, “As far as I’m concerned, I’m really not there yet.” Quieter than Cindy and extremely considerate, Ms. Bessin is hardly recognizable out of costume, just one of the facts that helps keep her grounded.

“I drink absolutely no Champagne, and I don’t fit in Jean Paul Gaultier’s clothes,” she said, with a toned-down version of the self-deprecation she shares with Cindy.

Germany may have more money than its neighbors on the whole, but the middle class is shrinking and much of its recent gains in economic competitiveness came from labor-market changes that cut jobless benefits and pressured people to work, sometimes for as little as an additional $1.30 an hour. Cindy brought the low-paying jobs and the secondhand stores onstage, with songs as well as monologues.

It was a language Ms. Bessin spoke fluently, having herself lived on Hartz IV welfare payments for several years. “You sleep a lot, because you don’t see the point in getting up, and you eat what’s around you,” Ms. Bessin recalled. “You go to the employment office because you have appointments, but generally you go home even more demoralized.”

Out of the crucible of humiliation emerged Cindy, crass and cagey, driven by appetites. She hides a bratwurst in a banana peel and asks the audience for chocolate, then eats what they throw onstage. “I have Alzheimer’s bulimia,” Cindy likes to say, stomach bulging under her pink sweatshirt, tiara perched atop her wig. “I eat everything in sight and then forget to throw up.”

Critics call her act offensive, lowbrow and worse, mixing high-minded attacks on her with patronizing depictions of her supposedly benighted fans. Those fans answer by buying her concert videos and turning out to her shows in droves, where they scream and applaud like mad, many wearing their own tiaras and pink sweatshirts emblazoned with the words “Alzheimer’s bulimia” on the front.

Cindy regales them with tales of her time as a member of the Socialist Children’s Television Ballet or her efforts to get adopted by Zsa Zsa Gabor’s husband Frédéric Prinz von Anhalt. Her performances are marathons with musical numbers. Fans often bring her presents and handmade cards. She is a star but also a hero, one of them, one who made it.

“I win,” Cindy sings in one of her songs, “although I’m not a winner.”

Ms. Bessin said in the interview that her act was not about East and West, which are outdated concepts in her view. Cindy happened to come from the East because Ms. Bessin did too. Her memory of the end of Communism was typically understated. “My mother was in the living room. I was in the kitchen washing dishes. She said, ‘The Wall fell,’ and I said, ‘Yeah, O.K.,’ and went back to washing dishes.”

Over the next decade she worked a dozen jobs at hotels and restaurants, including Planet Hollywood Berlin, and even did a stint on a cruise ship. She was working as a restaurant manager in 2001 and went on sick leave. When she came back she had been fired and her job had been given to someone else.

A long, demoralizing stretch on welfare followed. Between her hundreds of job applications Ms. Bessin said she ate, lay in bed and watched television, gaining weight and losing motivation. She was slowly sliding into a growing German underclass best known to the rest of the country from talk shows about paternity tests and plastic surgery. Unbeknown to Ms. Bessin, she was researching a character that had not yet found her outlet. Ms. Bessin’s break was not just lucky, it was accidental. In 2004, she called up the Quatsch Comedy Club in Berlin looking for a job as a waitress. After listening to her for a while the man on the other end of the line announced that he was not the person responsible for hiring service personnel. He was in charge of booking the acts.

“Do you have any interest in doing stand-up?” she recalled him asking. He told her about a talent competition the club was hosting. She agreed and began writing a few minutes of material. When she read through her jokes at rehearsal, people told her there was no way her act was going to work.

She decided she had nothing to lose; the wig and the costume were like a disguise and a suit of armor all at once. “No one is going to recognize me anyway, I thought,” Ms. Bessin said. On stage during the actual performance, the crowd responded immediately. Ms. Bessin talks about the similarities between her stage persona and herself, saying Cindy is “80 percent me,” but she talks about the character in the third person. Donning the costume unlocks something impish and ferocious in Ms. Bessin. She won the grueling competition, and eventually earned an appearance on the popular late-night show “TV total” in March 2006.

More offers to perform quickly followed. In 2007, Ms. Bessin won the German Comedy Prize for newcomer of the year. She has a comedy showcase, “Cindy and the Young Wild Ones,” on the private television network RTL.

The set for her first comedy special, “Schizophrenic: I Wanted to Be a Princess,” was a Communist housing bloc. The second, “Not Every Prince Comes on Horseback,” was a pink fairy castle, a home fit for Barbie.

The former welfare queen stood onstage, soaking up the audience’s applause, surrounded by men with guts, a few of them bald, but all wearing skimpy shorts and shaking pink and black pom-poms. Maybe none of them was Enrico, but it was certainly a dream come true.

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